Similar effects were established, necessitating further experiments to identify the active molecules involved. There are different types of proanthocyanidins and it’s thought that the molecules work together to achieve the effects observed.įurther tests were carried out to investigate whether the same pattern existed in a preliminary animal model: infected insects. The researchers suggested that central to this activity are molecules called proanthocyanidins. This provides evidence as to why the drug appears to be more effective in lower doses. This resulted in the antibiotic being able to penetrate the bacteria more easily, and the bacteria struggling to get rid of the drug. The extract was considered to alter the mechanism typically used by the bacteria to get rid of the antibiotic as well as increasing the permeability of the bacterial cell wall. It was found that cranberries increased bacterial sensitivity through two mechanisms. How did the COVID-19 pandemic impact the epidemiology of antibiotic resistant bacteria?.
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